Publications from the Molecular Structural Biology Group


2016


Lee C, Wigren E, Lünsdorf H, Römling U. (2016) Protein homeostasis-more than resisting a hot bath. Curr Opin Microbiol. 30:147-54. Medline

Katharina Brunner, Selma Maric, Rudraraju Srilakshmi Reshma, Helena Almqvist, Brinton Seashore-Ludlow, Anna-Lena Gustavsson, Ömer Poyraz, Perumal Yogeeswari, Thomas Lundbäck, Michaela Vallin, Dharmarajan Sriram, Robert Schnell, and Gunter Schneider (2016) Inhibitors of the Cysteine Synthase CysM with Antibacterial Potency against Dormant Mycobacterium tuberculosis. J. Med. Chem. 59, 6848–6859. Medline

Siitonen V, Selvaraj B, Niiranen L, Lindqvist Y, Schneider G, Metsä-Ketelä M. (2016) Divergent non-heme iron enzymes in the nogalamycin biosynthetic pathway. Proc Natl Acad Sci U S A. 113, 5251-5256. Medline

Stellmacher, L., Sandalova, T., Schneider, S., Schneider, G., Sprenger,G.A., Samland A. (2016) Novel mode of inhibition by D-tagatose-6-phosphate through a Heyns rearrangement in the active site of transaldolase B variants. Acta Cryst. D72, 467-476. Medline

Jacewicz, A., Schnell, R., Lindqvist, Y., Schneider, G. (2016) Crystal structure of the flavoenzyme PA4991 from Pseudomonas aeruginosa. Acta Cryst. F72, 105-111. Medline

2015

Moynié L, Hope AG, Finzel K, Schmidberger J, Leckie SM, Schneider G, Burkart MD, Smith AD, Gray DW, Naismith JH (2015) Substrate Mimic Allows High-Throughput Assay of the FabA Protein and Consequently the Identification of a Novel Inhibitor of Pseudomonas aeruginosa FabA. J Mol Biol. doi: 10.1016/j.jmb.2015.10.027. Medline

Lena Stellmacher, Tatyana Sandalova, Sebastian Leptihn, Gunter Schneider, Georg A. Sprenger, Anne K. Samland (2015) Acid-Base catalyst discriminates between a fructose 6-phosphate aldolases and a transaldolase. ChemCatChem 7, 3140-3151.  Medline

Baum B, Lecker LS, Zoltner M, Jaenicke E, Schnell R, Hunter WN, Brenk R. (2015) Structures of Pseudomonas aeruginosa β-ketoacyl-(acyl-carrier-protein) synthase II (FabF) and a C164Q mutant provide templates for antibacterial drug discovery and identify a buried potassium ion and a ligand-binding site that is an artefact of the crystal form. Acta Crystallogr F. 71:1020-6.  Medline

Possner DD, Claesson M, Guy JE. (2015) Structure of the Glycosyltransferase Ktr4p from Saccharomyces cerevisiae. PLoS One. 10(8):e0136239. Medline

Liu Q, Chai J, Moche M, Guy J, Lindqvist Y, Shanklin J. (2015) Half-of-the-Sites Reactivity of the Castor Δ9-18:0-Acyl Carrier Protein Desaturase. Plant Physiol. 169(1):432-441. Medline

Schnell, R., Sriram, D. and Schneider, G. (2015) Pyridoxal-phosphate dependent mycobacterial cysteine synthases: structure, mechanism and potential as drug targets. BBA - Proteins and Proteomics 1854, 1175-1183. Medline

Lee C, Wigren E, Trček J, Peters V, Kim J, Hasni MS, Nimtz M, Lindqvist Y, Park C, Curth U, Lünsdorf H, Römling U. (2015) A novel protein quality control mechanism contributes to heat shock resistance of world-wide distributed Pseudomonas aeruginosa clone C strains. Environ Microbiol. [Epub ahead of print] Medline

Xu J, Eriksson SE, Cebula M, Sandalova T, Hedström E, Pader I, Cheng Q, Myers CR, Antholine WE, Nagy P, Hellman U, Selivanova G, Lindqvist Y, Arnér ES. (2015) The conserved Trp114 residue of thioredoxin reductase 1 has a redox sensor-like function triggering oligomerization and crosslinking upon oxidative stress related to cell death. Cell Death Dis. 6:e1616. Medline

Poyraz Ö, Brunner K, Lohkamp B, Axelsson H, Hammarström LG, Schnell R, Schneider G. (2015) Crystal Structures of the Kinase Domain of the Sulfate-Activating Complex in Mycobacterium tuberculosis. PLoS One. 10:e0121494. Medline

Schmidberger JW, Schnell R, Schneider G. (2015) Structural characterization of substrate and inhibitor binding to farnesyl pyrophosphate synthase from Pseudomonas aeruginosa. Acta Crystallogr D71:721-731. Medline

Romanov RA, Alpár A, Zhang MD, Zeisel A, Calas A, Landry M, Fuszard M, Shirran SL, Schnell R, Dobolyi Á, Oláh M, Spence L, Mulder J, Martens H, Palkovits M, Uhlen M, Sitte HH, Botting CH, Wagner L, Linnarsson S, Hökfelt T, Harkany T. (2015) A secretagogin locus of the mammalian hypothalamus controls stress hormone release. EMBO J. 34:36-54. Medline

2014

Steiner EM, Böth D, Lössl P, Vilaplana F, Schnell R, Schneider G. (2014) CysK2 from Mycobacterium tuberculosis is an O-Phospho-L-Serine Dependent S-Sulfocysteine Synthase. J Bacteriol. 196:3410-20. Medline

Dobritzsch D, Wang H, Schneider G, Yu S.(2014) Structural and functional characterization of ochratoxinase, a novel mycotoxin degrading enzyme. Biochem J. 462:441-52. Medline

Ponnusamy R, Lebedev AA, Pahlow S, Lohkamp B. (2014) Crystal structure of human CRMP-4: correction of intensities for lattice-translocation disorder. Acta Crystallogr D Biol Crystallogr. 70:1680-94. Medline

Marteyn BS, Karimova G, Fenton AK, Gazi AD, West N, Touqui L, Prevost MC, Betton JM, Poyraz O, Ladant D, Gerdes K, Sansonetti PJ, Tang CM. (2014) ZapE is a novel cell division protein interacting with FtsZ and modulating the Z-ring dynamics. MBio. 5(2):e00022-14. Medline

Raposo B, Dobritzsch D, Ge C, Ekman D, Xu B, Lindh I, Förster M, Uysal H, Nandakumar KS, Schneider G, Holmdahl R (2014) Epitope-specific antibody response is controlled by immunoglobulin VH polymorphisms. J Exp Med. 211:405-411. Medline

Wigren E, Liang ZX, Römling U. (2014) Finally! The structural secrets of a HD-GYP phosphodiesterase revealed. Mol Microbiol. 91:1-5. Medline 

Böth D, Steiner EM, Izumi A, Schneider G, Schnell R. (2014) RipD (Rv1566c) from Mycobacterium tuberculosis: adaptation of an NlpC/p60 domain to a non-catalytic peptidoglycan-binding function. Biochem J. 457:33-41. Medline 


2013


Ahmad I, Wigren E, Le Guyon S, Vekkeli S, Blanka A, El Mouali Y, Anwar N, Chuah ML, Lünsdorf H, Frank R, Rhen M, Liang ZX, Lindqvist Y, Römling U. (2013) The EAL-like protein STM1697 regulates virulence phenotypes, motility and biofilm formation in Salmonella typhimurium. Mol Microbiol. 90:1216-32. Medline 

Cukier CD, Hope AG, Elamin AA, Moynie L, Schnell R, Schach S, Kneuper H, Singh M, Naismith JH, Lindqvist Y, Gray DW, Schneider G. (2013)  Discovery of an Allosteric Inhibitor Binding Site in 3-Oxo-acyl-ACP Reductase from Pseudomonas aeruginosa. ACS Chem Biol. 8(11):2518-27. Medline 

Keimpema E, Zheng K, Barde SS, Berghuis P, Dobszay MB, Schnell R, Mulder J, Luiten PG, Xu ZD, Runesson J, Langel U, Lu B, Hökfelt T, Harkany T. (2013) GABAergic Terminals Are a Source of Galanin to Modulate Cholinergic Neuron Development in the Neonatal Forebrain. Cereb Cortex. Medline

Poyraz O, Jeankumar VU, Saxena S, Schnell R, Haraldsson M, Yogeeswari P, Sriram D, Schneider G. (2013) Structure-Guided Design of Novel Thiazolidine Inhibitors of O-Acetyl Serine Sulfhydrylase from Mycobacterium tuberculosis. J Med Chem. 56:6457-6466. Medline

Chen MW, Lohkamp B, Schnell R, Lescar J, Schneider G. (2013) Substrate Channel Flexibility in Pseudomonas aeruginosa MurB Accommodates Two Distinct Substrates. PLoS One 8:e66936. Medline

Jacewicz A, Izumi A, Brunner K, Schnell R, Schneider G. (2013) Structural insights into the UbiD protein family from the crystal structure of PA0254 from Pseudomonas aeruginosa. PLoS One 9 :e63161. Medline 

Zheng C, Page RC, Das V, Nix JC, Wigren E, Misra S, Zhang B. (2013) Structural Characterization of Carbohydrate Binding by LMAN1 Protein Provides New Insight into the Endoplasmic Reticulum Export of Factors V (FV) and VIII (FVIII). J Biol Chem. 288:20499-509. Medline

Biterova EI, Svärd M, Possner DD, Guy JE. (2013) Purification, crystallization and preliminary X-ray crystallographic analysis of the lumenal domain of the ER-vesicle protein Erv41p from Saccharomyces cerevisiae. Acta Crystallogr Sect F 69:544-6. Medline

Biterova EI, Svärd M, Possner DD, Guy JE. (2013) The crystal structure of the lumenal domain of Erv41p, a protein involved in transport between the endoplasmic reticulum and Golgi apparatus. J Mol Biol. 425:2208-18. Medline

Oja T, Niiranen L, Sandalova T, Klika KD, Niemi J, Mäntsälä P, Schneider G, Metsä-Ketelä M. (2013) Structural basis for C-ribosylation in the alnumycin A biosynthetic pathway. Proc Natl Acad Sci U S A. 110, 1291-1296. Medline

Jean Kumar VU, Poyraz O, Saxena S, Schnell R, Yogeeswari P, Schneider G, Sriram D. (2013) Discovery of novel inhibitors targeting the Mycobacterium tuberculosis O-acetylserine sulfhydrylase (CysK1) using virtual high-throughput screening. Bioorg Med Chem Lett. 23, 1182-1186. Medline

D. Böth, E. M. Steiner, D. Stadler, Y. Lindqvist, R. Schnell and G. Schneider (2013) Structure of LdtMt2, an L,D-transpeptidase from Mycobacterium tuberculosis. Acta Cryst D, 69:432-41. Medline

Moynie L, Schnell R, McMahon SA, Sandalova T, Boulkerou WA, Schmidberger JW, Alphey M, Cukier C, Duthie F, Kopec J, Liu H, Jacewicz A, Hunter WN, Naismith JH, Schneider G. (2013) The AEROPATH project targeting Pseudomonas aeruginosa: crystallographic studies for assessment of potential targets in early-stage drug discovery. Acta Cryst F 69, 25-34. Medline

Ponnusamy R, Lohkamp B. (2013) Insights into the oligomerization of CRMPs: Crystal structure of human collapsin response mediator protein 5. J Neurochem. 125(6):855-68. Medline

 
2012

Claesson M, Siitonen V, Dobritzsch D, Metsä-Ketelä M, Schneider G. (2012) Crystal structure of the glycosyltransferase SnogD from the biosynthetic pathway of nogalamycin in Streptomyces nogalater. FEBS J. 279:3251-63. Medline

Izumi A, Schnell R, Schneider G. (2012) , Crystal structure of NirD, the small subunit of the nitrite reductase NirbD from Mycobacterium tuberculosis at 2.0 Å resolution. Proteins, 80,2799-803.  Medline

Rodriguez PQ, Lohkamp B, Celsi G, Mache CJ, Auer-Grumbach M, Wernerson A, Hamajima N, Tryggvason K, Patrakka J. (2012), Novel INF2 mutation p. L77P in a family with glomerulopathy and Charcot-Marie-Tooth neuropathy. Pediatr Nephrol., 28(2):339-43. Medline

van Kuilenburg AB, Dobritzsch D, Meijer J, Krumpel M, Selim LA, Rashed MS, Assmann B, Meinsma R, Lohkamp B, Ito T, Abeling NG, Saito K, Eto K, Smitka M, Engvall M, Zhang C, Xu W, Zoetekouw L, Hennekam RC (2012), ß-ureidopropionase deficiency: phenotype, genotype and protein structural consequences in 16 patients. Biochim Biophys Acta. 1822, 1096-1108.  Medline

Chen MW, Kotaka M, Vonrhein C, Bricogne G, Rao F, Chuah ML, Svergun D, Schneider G, Liang ZX, Lescar J. (2012), Structural Insights into the Regulatory Mechanism of the Response Regulator RocR from Pseudomonas aeruginosa in Cyclic Di-GMP Signaling. J Bacteriol. 194, 4837-4846.  Medline

Coic YM, Baleux F, Poyraz O, Thibeaux R, Labruyere E, Chretien F, Sobhani I, Lazure T, Wyplosz B, Schneider G, Mulard L, Sansonetti PJ, Marteyn BS, (2012), Design of a specific colonic mucus marker using a human commensal bacterium cell-surface domain. J Biol Chem, 287(19):15916-22. Medline

Schnell R, Oehlmann W, Sandalova T, Braun Y, Huck C, Maringer M, Singh M, Schneider G, (2012), Tetrahydrodipicolinate N-Succinyltransferase and Dihydrodipicolinate Synthase from Pseudomonas aeruginosa: Structure Analysis and Gene Deletion. PloS One, 7, e31133Medline

Claesson M, Lindqvist Y, Madrid S, Sandalova T, Fiskesund R, Yu S, Schneider G, (2012), Crystal Structure of Bifunctional Aldos-2-Ulose Dehydratase/Isomerase from Phanerochaete chrysosporium with the Reaction Intermediate Ascopyrone M. J Mol Biol, 417, 279-293.  Medline

Samland AK, Baier S, Schürmann M, Inoue T, Huf S, Schneider G, Sprenger GA, Sandalova T, (2012), Conservation of structure and mechanism within the transaldolase enzyme family. FEBS J., 279, 766-778.  Medline

Dobritzsch D, Lindh I, Uysal H, Nandakumar KS, Burkhardt H, Schneider G, Holmdahl R (2012), Crystal structure of an arthritogenic anticollagen immune complex. Arthritis Rheum, 63, 3740-3748.  Medline

Siitonen V, Claesson M, Patrikainen P, Aromaa M, Mäntsälä P, Schneider G, Metsä-Ketelä M, (2012) Identification of late-stage glycosylation steps in the biosynthetic pathway of the anthracycline nogalamycin. Chembiochem, 2, 120-128Medline




2011

Rother D, Kolter G, Gerhards T. Berthold Siöberg CL, Gauchenova E, Knoll M, Pleiss J, Müller M, Schneider G and Pohl M (2011) S-Selective Mixed Carboligation by Structure-Based Design of the Pyruvate Decarboxylase from Acetobacter pasteurianus. ChemCatChem 3: 1587–1596. doi: 10.1002/cctc.201100054.

Kopec J, Schnell R, Schneider G, (2011) Structure of PA4019, a putative aromatic acid decarboxylase from Pseudomonas aeruginosaActa Cryst. F67, 1184 - 1188Link

Kopec J, Schneider G. (2011) Comparison of fluorescence and light scattering based methods to assess formation and stability of protein-protein complexes.  J Struct Biol. 175(2), 216-23Medline

Guy JE, Whittle E, Moche M, Lengqvist J, Lindqvist Y, Shanklin J. (2011) Remote control of regioselectivity in acyl-acyl carrier protein-desaturases. Proc Natl Acad Sci U S A. 108(40), 16594-9. Medline

Böth D, Schneider G, Schnell R. (2011) Peptidoglycan remodeling in Mycobacterium tuberculosis: comparison of structures and catalytic activities of RipA and RipB. J Mol Biol. 413(1), 247-60. Medline

Svärd M, Biterova EI, Bourhis JM, Guy JE. (2011) The crystal structure of the human co-chaperone P58(IPK). PLoS One. 6(7), e22337. Medline



2010

Lohkamp B, Voevodskaya N, Lindqvist Y, Dobritzsch D. (2010) Insights into the mechanism of dihydropyrimidine dehydrogenase from site-directed mutagenesis targeting the active site loop and redox cofactor coordination.Biochim Biophys Acta. 1804(12), 2198-206.Medline

van Kuilenburg AB, Meijer J, Mul AN, Meinsma R, Schmid V, Dobritzsch D, Hennekam RC, Mannens MM, Kiechle M, Etienne-Grimaldi MC, Klümpen HJ, Maring JG, Derleyn VA, Maartense E, Milano G, Vijzelaar R, Gross E. (2010)  Intragenic deletions and a deep intronic mutation affecting pre-mRNA splicing in the dihydropyrimidine dehydrogenase gene as novel mechanisms causing 5-fluorouracil toxicity. Hum Genet. 128(5), 529-38. Medline

Schnell R, Schneider G. (2010) Structural enzymology of sulphur metabolism in Mycobacterium tuberculosis. Biochem Biophys Res Commun. 396, 33-8. Medline

Emsley P, Lohkamp B, Scott WG, Cowtan K. (2010)  Features and development of Coot. Acta Crystallogr. D66, 486-501. Medline

van Kuilenburg AB, Dobritzsch D, Meijer J, Meinsma R, Benoist JF, Assmann B, Schubert S, Hoffmann GF, Duran M, de Vries MC, Kurlemann G, Eyskens FJ, Greed L, Sass JO, Schwab KO, Sewell AC, Walter J, Hahn A, Zoetekouw L, Ribes A, Lind S, Hennekam RC. (2010) Dihydropyrimidinase deficiency: Phenotype, genotype and structural consequences in 17 patients. Biochim Biophys Acta. 1802(7-8), 639-48. Medline

Schneider S, Gutiérrez M, Sandalova T, Schneider G, Clapés P, Sprenger GA, Samland AK.  (2010)  Redesigning the active site of transaldolase TalB from Escherichia coli: New variants with improved affinity towards nonphosphorylated substrates. Chembiochem. 11,681-690. Medline

Wigren E, Bourhis JM, Kursula I, Guy JE, Lindqvist Y. (2010) Crystal structure of the LMAN1-CRD/MCFD2 transport receptor complex provides insight into combined deficiency of factor V and factor VIII. FEBS Lett. 584(5), 878-82. Medline

Grocholski T,  Koskiniemi H, Lindqvist Y, Mäntsälä P, Niemi J, Schneider G.  (2010)  Crystal structure of the cofactor-independent monooxygenase SnoaB from Streptomyces nogalater: Implication for the reaction mechanism.  Biochemistry  49, 934-944. Medline


2009

Bourhis JM, Vignaud C, Pietrancosta N, Gueritte F, Guenard D, Lederer F, Lindqvist Y  (2009)  Structure of human glycolate oxidase in
complex with the inhibitor 4-carboxy-5-[(4-chlorophenyl)sulfanyl]-1,2,3-thiadiazoleActa Crystallogr. F65, 1246-1253. Medline


Lindqvist Y, 
Koskiniemi H, Jansson A, Sandalova T, Schnell R, Liu Z, Mäntsälä P, Niemi J, Schneider G   (2009)  Structural basis for substrate recognition and specificity in aklavinone-11-hydroxylase from rhodomycin biosynthesis. J Mol Biol. 693, 966-977. Medline

Silvennoinen L, Sandalova T, Schneider G  (2009)  The polyketide cyclase RemF from Streptomyces resistomycificus contains an unusual octahedral zinc binding site. FEBS Lett. 583, 2917-2121. Medline

Ekström F, Hörnberg A, Artursson E, Hammarström LG, Schneider G, Pang YP (2009) Structure of HI6 Sarin-acetylcholinesterase determined by X-Ray crystallography and molecular dynamic simulation:reactivator mechanism and design. PLOSOne 4, e5957, 1-19 Medline

Guy JE, Ståhl U, Lindqvist Y.(2009)  Crystal structure of a class XIB Phospholipase A2: rice (Oryza sativa) isoform-2  PLA2 and an octanoate complex. J Biol Chem. 284, 19371-19377. Medline

Viklund IM, Aspenström P, Meas-Yedid V, Zhang B, Kopec J, Agren D, Schneider G, D'Amato M, Olivo-Marin JC, Sansonetti P, Van Nhieu GT, Pettersson S. (2009) WAFL, a new protein involved in regulation of early endocytic transport at the intersection of actin and microtubule dynamics. Exp Cell Res. 315, 1040-1052 Medline

Shanklin J, Guy JE, Mishra G, Lindqvist Y. (2009)  Desaturases - emerging models for understanding functional diversification of diiron-containing enzymes. J Biol Chem. 284, 18559-18563. Medline

Koskiniemi H, Grocholski T, Schneider G, Niemi  J 
(2009) Expression, purification and crystallization of the cofactor-independent monooxygenase SnoaB from the nogalamycin biosynthetic pathway.  Acta Crystallogr. F65, 256-259. Medline

Agren D, Schnell R.,  Schneider G.  (2009) The C-terminal of CysM from Mycobacterium tuberculosis protects the aminoacrylate intermediate and is involved in sulfur donor selectivity  Febs Lett.  583, 330-336 Medline

Cheng Q, Sandalova T, Lindqvist Y, Arnér ES. (2009) Crystal structure and catalysis of the selenoprotein thioredoxin reductase 1. J Biol Chem. 284, 3998-4008 Medline


2008

Beck H, Dobritzsch D, Piskur J. (2008)  Saccharomyces kluyveri as a model organism to study pyrimidine degradation. FEMS Yeast Res. 8, 1209-1213. Medline

Metsä-Ketelä M, Niemi J, Mäntsälä P and Schneider G. (2008)  Antracycline biosynthesis: gens, enzymes and mechanisms.  Top. Curr. Chem., 282,101-143. Medline

Schnell R,  Agren D,  Schneider G. (2008) 1.9 A structure of the signal receiver domain of the putative response regulator NarL from Mycobacterium tuberculosis.  Acta Crystallogr. F64, 1096-1100 Medline

Agren D, Schnell R, Oehlmann W, Singh M, Schneider G. (2008) Cysteine synthase (CYSM) of mycobacterium tuberculosis is an O-phosphoserine sulfhydrylase: Evidence for an alternative cysteine biosynthesis pathway in mycobacteria.  J Biol Chem. 283, 31567-31574. Medline

Schneider S, Sandalova T, Schneider G, Sprenger GA, Samland AK. (2008)  Replacement of a phenylalanine by a tyrosine in the active site confers fructose 6-phosphate aldolase activity to the transaldolase of Escherichia coli and human origin.  J Biol Chem. 283, 30064-30072.  Medline

van Kuilenburg AB, Meijer J, Dobritzsch D, Lohkamp B, Ruitenbeek W, Roelofsen J, Abeling NG, Duran M, Buzing C. (2008) Identification of Two Novel Mutations C79X and R235Q in the Dihydropyrimidine Dehydrogenase Gene in a Patient Presenting With Hematuria. Nucleosides Nucleotides Nucleic Acids. 27, 809-815.  Medline

Schnackerz KD, Andersen G, Dobritzsch D, Piskur J. (2008)  Degradation of pyrimidines in Saccharomyces kluyveri: transamination of beta-alanine.  Nucleosides Nucleotides Nucleic Acids. 27, 794-799. Medline

Guy JE, Wigren E, Svärd M, Härd T, Lindqvist Y. (2008). New insights into multiple coagulation factor deficiency from the solution structure of human MCFD2. J Mol Biol. 381, 941-955  Medline

Marienhagen J, Sandalova T, Sahm H, Eggeling L, Schneider G. (2008) Insights into the structural basis of substrate recognition by histidinol-phosphate aminotransferase from Corynebacterium glutamicum. Acta Crystallogr. D64, 675-685.   Medline

Andersen B, Lundgren S, Dobritzsch D, Piškur J. (2008)  A Recruited protease is involved in catabolism of pyrimidines. J Mol Biol. 379,   243-250.  Medline

Lohkamp B, Dobritzsch D. (2008)  A mixture of fortunes: the curious determination of the structure of Escherichia coli BL21 Gab protein. Acta Crystallogr. D64, 407-415.  Medline

Lundgren S, Lohkamp B, Andersen B, Piškur J, Dobritzsch D. (2008)  The Crystal structure of beta-Alanine synthase from Drosophila melanogaster reveals a homooctameric helical turn-like assembly.  J Mol Biol.  377, 1544-1559  Medline

Schnackerz KD, Dobritzsch D. (2008) Amidohydrolases of the reductive pyrimidine catabolic pathway. Purification, characterization, structure, reaction mechanisms and enzyme deficiency. Biochim Biophys Acta. 1784, 431-444.  Medline

Agren D, Stehr M, Berthold CL, Kapoor S, Oehlmann W, Singh M, Schneider G.(2008) Three-dimensional structures of apo- and holo-l-alanine dehydrogenase from Mycobacterium tuberculosis reveal conformational changes upon coenzyme binding. J Mol Biol. 377, 1161-1173  Medline

Toyota CG, Berthold CL, Gruez A, Jónsson S, Lindqvist Y, Cambillau C, Richards NG. (2008)  Differential substrate specificity and kinetic behavior in Escherichia coli YfdW and  Oxalobacter formigenes formyl-CoA transferase.  J Bacteriol. 190, 2556-2564.
Medline

Gocke D, Walter L, Gauchenova E, Kolter G, Knoll M, Berthold CL, Schneider G, Pleiss J, Müller M, Pohl M. (2008)  Rational protein design of ThDP-dependent enzymes-engineering stereoselectivity.  Chembiochem. 15, 406-412. 
Medline

Berthold CL, Toyota CG, Richards NG, Lindqvist Y. (2008)  Re-investigation of the catalytic mechanism of formyl-CoA transferase, a class III CoA-transferase. J Biol Chem. 283, 6519-6529.  Medline


2007



Banci L, Baumeister W, Heinemann U, Schneider G, Silman I, Stuart DI, Sussman JL. (2007)  An idea whose time has come. Genome Biol. 8, 408-409.  Medline

Lindqvist Y, Hunter WN. (2007)  Going through the motions; lessons from haemoglobin, hard work driven by ATP, dealing with ammonia and frustrations in drug discovery. Curr Opin Struct Biol. 17, 631-632. Medline

Berthold CL, Gocke D, Wood MD, Leeper FJ, Pohl M, Schneider G. (2007) Structure of the branched-chain keto acid decarboxylase (KdcA) from  Lactococcus lactis provides insights into the structural basis for the chemoselective and enantioselective carboligation reaction. Acta Crystallogr. D63, 1217-1224. Medline

Ghosal A, Banas A, Ståhl U, Dahlqvist A, Lindqvist Y, Stymne S. (2007) Saccharomyces cerevisiae phospholipid:diacylglycerol acyl transferase (PDAT) devoid of its membrane anchor region is a soluble and active enzyme retaining its substrate specificities. Biochim Biophys Acta. 1771, 1457-1463.  Medline

Lundgren S, Andersen B, Piskur J, Dobritzsch D. (2007) Crystal structures of yeast beta -alanine synthase complexes reveal the mode of substrate binding and large-scale domain closure movements. J Biol Chem. 282, 36037-36047.  Medline

Lundgren S, Andersen B, Piskur J, Dobritzsch D. (2007) Crystallization and preliminary X-ray data analysis of beta-alanine synthase from  Drosophila melanogaster. Acta Crystallogr. F63, 874-877.Medline

Koskiniemi H, Metsa-Ketela M, Dobritzsch D, Kallio P, Korhonen H, Mantsala P, Schneider G, Niemi J. (2007) Crystal structures of two aromatic hydroxylases involved in the early tailoring steps of angucycline biosynthesis. J Mol Biol.  372, 633-648. Medline

Schnell R, Oehlmann W, Singh M, Schneider G. (2007) Structural insights into catalysis and inhibition of O-acetylserine sulfhydrylase from Mycobacterium tuberculosis: Crystal structures of the enzyme - alpha -aminoacrylate intermediate and an enzyme-inhibitor complex. J Biol Chem. 282, 23473-23481. Medline

Berthold CL, Toyota CG, Moussatche P, Wood MD, Leeper F, Richards NG, Lindqvist Y. (2007) Crystallographic snapshots of oxalyl-CoA decarboxylase give insights into catalysis by nonoxidative ThDP-dependent decarboxylases. Structure 15, 853-861. Medline

Gustafsson TN, Sandalova T, Lu J, Holmgren A, Schneider G.(2007) High-resolution structures of oxidized and  reduced thioredoxin reductase from Helicobacter pylori. Acta Crystallogr D63, 833-843.Medline

Guy JE, Whittle E, Kumaran D, Lindqvist Y, Shanklin J. (2007)  The crystal structure of the ivy d4 -16:0-ACP desaturase reveals structural details of the oxidized active site and    potential determinants of regio-selectivity.   J Biol Chem.  282, 19863-19871. Medline

Ojala JR, Pikkarainen T, Tuuttila A, Sandalova T, Tryggvason K.(2007)  Crystal structure of the cysteine-rich domain of scavenger receptor Marco reveals the presence of a basic and an acidic cluster that both contribute to ligand recognition. J Biol Chem. 282, 16654-16666  Medline

Alexeev I, Sultana A, Mantsala P, Niemi J, Schneider G.(2007)   Aclacinomycin oxidoreductase (AknOx) from the biosynthetic pathway of the antibiotic aclacinomycin is an unusual flavoenzyme with a dual active site.  Proc Natl Acad Sci U S A. 104, 6170-6175. Medline

Andersen G, Andersen B, Dobritzsch D, Schnackerz KD, Piskur J. (2007)  A gene duplication led to specialized gamma-aminobutyrate and beta-alanine aminotransferase in yeast. FEBS J.  274, 1804-1817. Medline

van Kuilenburg AB, Meijer J, Dobritzsch D, Meinsma R, Duran M, Lohkamp B, Zoetekouw L, Abeling NG, van Tinteren HL, Bosch AM. (2007) Clinical, biochemical and genetic findings in two siblings with a  dihydropyrimidinase deficiency. Mol Genet Metab. 91, 157-164. Medline

Banci, L., Baumeister, W., Enfedaque, J., Heinemann, U., Schneider, G., Silman, I. and Sussman, J.L. (2007) Structural Proteomics: from the molecule to the system. Nat. Struct. & Mol. Biol. 14, 3-4 Medline

Sultana A, Alexeev I, Kursula I, Mantsala P, Niemi J, Schneider G.  (2007)  Structure determination by multiwavelength anomalous diffraction of aclacinomycin oxidoreductase: indications of multidomain pseudomerohedral twinning. Acta  Crystallogr D63, 149-159. Medline

 

2006


Andersen G, Merico A, Bjornberg O, Andersen B, Schnackerz KD, Dobritzsch D, Piskur J, Compagno C.  (2006) Catabolism of pyrimidines in yeast: a tool to understand degradation of anticancer drugs. Nucleosides Nucleotides Nucleic Acids. 25, 991-996. Medline

Guy JE, Abreu IA, Moche M, Lindqvist Y, Whittle E, Shanklin J. (2006) A single mutation in the castor {Delta}9-18:0-desaturase changes  reaction partitioning from desaturation to oxidase chemistry.  Proc Natl Acad Sci U S A 103, 17220-17224. Medline

Banci L, Bertini I, Cusack S, de Jong RN, Heinemann U, Jones EY, Kozielski F, Maskos K, Messerschmidt A, Owens R, Perrakis A, Poterszman A, Schneider G, Siebold C, Silman I, Sixma T, Stewart-Jones G, Sussman JL, Thierry JC,  Moras D. (2006) First steps towards effective methods in exploiting high-throughput technologies for the determination of human protein structures  of high biomedical value. Acta  Crystallogr D62, 1208-1217. Medline 

Aricescu AR, Assenberg R,  Bill RM, Busso D, Chang VT, Davis SJ, Dubrovsky A, Gustafsson L, Hedfalk K, Heinemann U, Jones IM, Ksiazek D, Lang C, Maskos K, Messerschmidt A, Macieira S, Peleg Y, Perrakis A, Poterszman A, Schneider G, Sixma  TK, Sussman JL, Sutton G,  Tarboureich N,  Zeev-Ben-Mordehai T, Jones EY (2006) Eukaryotic expression: developments for structural proteomics. Acta Crystallogr D62, 1114-1124.  Medline

Fogg MJ, Alzari P, Bahar M, Bertini I, Betton JM, Burmeister WP, Cambillau C, Canard B,
Carrondo M, Coll M, Daenke S, Dym O, Egloff MP, Enguita FJ, Geerlof A, Haouz A, Jones TA, Ma Q, Manicka SN, Migliardi M, Nordlund P, Owens RJ, Peleg Y, Schneider G, Schnell R, Stuart DI, Tarbouriech N, Unge T, Wilkinson AJ, Wilmanns M, Wilson KS, Zimhony O, Grimes JM (2006) Application of the use of high-throughput technologies to the determination of protein structures of bacterial and viral pathogens. Acta Crystallogr D62, 1196-1207. Medline

Lohkamp B, Bauerle B, Rieger PG, Schneider G. (2006) Three-dimensional structure of iminodisuccinate epimerase defines the fold of the MmgE/PrpD protein family.  J Mol Biol.  362, 555-566. Medline

Bauerle B, Sandalova, T., Schneider, G. Rieger PG (2006)  Purification, crystallization and preliminary crystallographic study of an IDS-epimerase from Agrobacterium tumefaciens BY6. Acta Crystallogr F62, 746-749  Medline

Beinker P, Lohkamp B, Peltonen T, Niemi J, Mantsala P, Schneider G (2006)  Crystal Structures of SnoaL2 and AclR: Two Putative Hydroxylases in the Biosynthesis of Aromatic Polyketide AntibioticsJ Mol Biol  359, 728-740 Medline

Lohkamp B, Andersen B, Piskur J, Dobritzsch D (2006) The crystal structures of dihydropyrimidinases reaffirm the close relationship between cyclic amidohydrolases and explain their substrate specificity.  J Biol Chem  281, 13762-13776  Medline

Mkrtchian S, Sandalova T (2006) ERp29, an Unusual Redox-Inactive Member of the Thioredoxin Family.  Antioxid Redox Signal  8, 325-337.Medline

Cerboni C, Achour A, Warnmark A, Mousavi-Jazi M, Sandalova T, Hsu ML, Cosman D, Karre K, Carbone E (2006)  Spontaneous mutations in the human CMV HLA class I homologue UL18 affect its binding to the inhibitory receptor LIR-1/ILT2/CD85j.  Eur J Immunol  36, 732-741. Medline

Kallio P, Sultana A, Niemi J, Mantsala P, Schneider G (2006)  Crystal structure of the polyketide cyclase AknH with bound substrate and product analogue: implications for catalytic mechanism and product stereoselectivity.  J Mol  Biol 357, 210-220.  Medline

Achour A, Michaelsson J, Harris RA, Ljunggren HG, Karre K, Schneider G, Sandalova T (2006) Structural Basis of the Differential Stability and  Receptor Specificity of H-2D(b) in Complex with Murine versus Human beta(2)-Microglobulin. J Mol Biol  356, 382-396 Medline

Berthold CL, Sidhu H, Ricagno S, Richards NG, Lindqvist Y (2006) Detection and characterization of merohedral twinning in crystals of oxalyl-coenzyme A decarboxylase from Oxalobacter formigenes. Biochim Biophys Acta. 1764, 122-128.Medline

Lohkamp B, Andersen B, Piskur J, Dobritzsch D (2006) Purification, crystallization and X-ray diffraction analysis of dihydropyrimidinase from Dictyostelium discoideum.  Acta Crystallogr F62, 36-38. Medline

2005

 

Schneider G  (2005). Enzymes in the biosynthesis of aromatic polyketide antibiotics. Curr. Opin. Struct. Biol. 15, 629-636 Medline

Sandalova, T., Michaëlsson, J., Harris, R.A., Ljunggren, H.G., Kärre, K., Schneider, G. and Achour A (2005)  Expression, refolding and crystallization of murine MHC class I H-2Db in complex with human β2m-microglobulin. Acta Crystallogr F61, 1090-1093  Medline

Dobritzsch D. , Andersen B. and Pikur J
(2005) Crystallization and X-ray diffraction analysis of dihydropyrimidinase from Saccharomyces kluyveri  Acta Crystallogr  F61, 359-362.  Medline

Berthold CL, Moussatche P, Richards NG, Lindqvist Y
(2005) Structural basis for activation of the thiamin diphosphate-dependent enzyme oxalyl-CoA decarboxylase by adenosine diphosphate. J Biol Chem  280, 41645-41654. Medline

Berthold CL, Sidhu H, Ricagno S, Richards NG, Lindqvist Y
(2005) Detection and characterization of merohedral twinning in crystals of oxalyl-coenzyme A decarboxylase from Oxalobacter formigenes. Biochim Biophys Acta 1764, 122-128. Medline

Van Kuilenburg AB, Meinsma R, Beke E, Bobba B, Boffi P, Enns GM, Witt DR, Dobritzsch D
(2005) Identification of three novel mutations in the dihydropyrimidine dehydrogenase gene associated with altered pre-mRNA splicing or protein function. Biol Chem 386, 319-324. Medline

Schnell R, Sandalova T, Hellman U, Lindqvist Y, Schneider G
(2005) Siroheme- and [Fe4-S4]-dependent NirA from Mycobacterium tuberculosis is a sulfite reductase with a covalent Cys-Tyr bond in the active site. J Biol Chem  280, 27319-27328.   Medline

Sandalova T, Michaelsson J, Harris RA, Odeberg J, Schneider G, Karre K, Achour A
(2005) A structural basis for CD8+ T cell-dependent recognition of non-homologous peptide ligands: implications for molecular mimicry in autoreactivity. J Biol Chem 280, 27069-27075. Medline

Jansson A, Koskiniemi H, Erola A, Wang J, Mäntsälä P, Schneider G, and Niemi  J
(2005) Aclacinomycin-10-hydroxylase is a novel substrate-assisted hydroxylase requiring S-adenosyl-L-methionine as cofactor. J. Biol. Chem. 280, 3636-3644  Medline
 
Golbik R, Meshalkina L, Sandalova T, Tittmann K, Fiedler E, Neef H, König S, Kluger R, Kochetov GA, Schneider G. and Hübner G.
(2005) Effect of coenzyme modification on the structural and catalytic properties of wild-type transketolase and of the variant E418A from Saccharomyces cerevisiae. Contrasting protonation state requirements of thiamin diphosphate in decarboxylases and transketolases. FEBS Journal  272, 1326-1342  Medline

Svedruzic D, Jonsson S, Toyota CG, Reinhardt LA, Ricagno S, Lindqvist Y,  Richards NG
(2005) The enzymes of oxalate metabolism: unexpected structures and mechanisms.  Arch Biochem Biophys. 433, 176-192. Review  Medline

2004



Schnackerz KD, Dobritzsch D, Lindqvist Y, Cook PF
(2004)  Dihydropyrimidine dehydrogenase: a flavoprotein with four iron-sulfur clusters. Biochim Biophys Acta. 1701, 61-74. Medline

 
Jansson A, Koskiniemi H, Mantsala P, Niemi J, and Schneider G. (2004) Crystal structure of a ternary complex of DnrK, a methyltransferase in daunorubicin biosynthesis, with bound products. J Biol Chem. 279, 41149-41156. Medline

Jonsson S, Ricagno S, Lindqvist Y, and Richards NG. (2004) Kinetic and Mechanistic Characterization of the Formyl-CoA Transferase from Oxalobacter formigenes. J Biol Chem. 279, 36003-36012. Medline


Dolzan M, Johansson K, Roig-Zamboni V, Campanacci V, Tegoni M, Schneider G, and Cambillau C
(2004) Crystal structure and reactivity of YbdL from Escherichia coli identify a methionine aminotransferase function. FEBS Lett 571, 141-146. Medline

Veitch NJ, Maugeri DA, Cazzulo JJ, Lindqvist Y, and Barrett  MP
(2004) Transketolase from Leishmania mexicana has a dual subcellular localization. Biochem J  382, 759-767. Medline

Stehr M  and Lindqvist Y (2004)  NrdH-redoxin of Corynebacterium ammoniagenes forms a domain-swapped dimer. Proteins  55, 613-619 Medline

Sultana A, Kallio K, Jansson A, Wang J-S, Niem, J, Mäntsälä P, and Schneider G.(2004) Crystal structure of the polyketide cyclase SnoaL reveals a novel mechanism for enzymatic aldol condensation, EMBO J   23,1911-1921.  Medline


Sultana A, Kallio K, Jansson A, Niemi J, Mäntsälä P, and Schneider G.
(2004) Crystallisation and preliminary crystallographic data of SnoaL, a polyketide cyclase in nogalamycin biosynthesis. Acta Crystallogr. D60, 1118-1120 Medline

 

Velloso L M., Michaelson J, Ljunggren HG, Schneider G. and Achour A. (2004) Determination of structural principles underlying three different modes of lymphocytic choriomeningitis virus escape from CTL recognition.  J. Immunol  172, 5504-5511  Medline


Ricagno S, Grolle S, Bringer-Meyer S, Sahm H, Lindqvist Y and Schneider G.
(2004) Crystal structure of 1-deoxy-D-xylulose-5-phosphate reductoisomerase from Zymomonas mobilis at 1.9 Å resolution. Biochem. Biophys. Acta. 1698, 37-44. Medline

 

Sandmark J, Eliot AC, Famm K, Schneider G. and  Kirsch JF (2004) Conserved and Nonconserved Residues in the Substrate Binding Site of 7,8-Diaminopelargonic Acid Synthase from Escherichia coli Are Essential for Catalysis. Biochemistry  43, 1213-1222. Medline

 

2003

 

 

Velloso LM, Svensson K, Pettersson RF and Lindqvist Y (2003)  The Crystal Structure of the Carbohydrate-recognition Domain of the Glycoprotein Sorting Receptor p58/ERGIC-53 Reveals an Unpredicted Metal-binding Site and Conformational Changes Associated with Calcium Ion Binding   J Mol Biol 334, 845-851. Medline


Lundgren S, Gojkovic Z, Piskur J, Dobritzsch D. (2003) Yeast beta-alanine synthase shares a structural scaffold and origin with dizinc-dependent exopeptidases. J Biol Chem. 278, 51851-51862. Medline


Kaiser L, Gronlund H, Sandalova T, Ljunggren HG, van Hage-Hamsten M, Achour A, Schneider G. (2003) The crystal structure of the major cat allergen Fel d 1, a member of the secretoglobin family. J Biol Chem. 278, 37730-37735.
Medline


Jansson  A, Niemi J, Lindqvist Y, Mäntsälä P and Schneider G. (2003) Crystal structure of aclacinomycin-10-hydroxylase, S-adenosyl--L-methionine-dependent methyltransferase homolog involved in anthracycline biosynthesis in Streptomyces purpurascens. J Mol Biol. 334, 269-280. Medline


Jansson A, Niemi J, Mäntsälä P and Schneider G. (2003) Crystal structure of aclacinomycin methylesterase with bound product analogues: implications for anthracycline recognition and mechanism.
J. Biol. Chem. 278, 39006-39013 Medline

Jansson A, Niemi J, Mäntsälä P, Schneider G. (2003).
Crystallization and preliminary X-ray diffraction studies of aclacinomycin-10-methyl esterase and aclacinomycin-10-hydroxylase  Acta Crystallogr. D59,1637-1639 Medline

Tittmann K, Golbik R, Uhlemann K, Khailova L, Schneider G, Patel M, Jordan F, Chipman DM, Duggleby RG and Hübner G. (2003) NMR analysis of covalent intermediates in thiamin diphosphate enzymes. Biochemistry 42, 7885-7891 Medline

Kaiser L, Grönlund H, Sandalova T, Ljunggren HG, Schneider G, Van Hage-Hamsten M, Achour A.(2003) Production,  crystallization and preliminary crystallographic study ofthe major cat allergen Fel d 1. Acta Crystallogr D59,1103-1105. Medline

 
Dobritzsch D, Gojkovic Z, Andersen B and Piskur J. (2003) Crystallization and preliminary X-ray analysis of beta-alanine synthase from the yeast Saccharomyces kluyveri. Acta Crystallogr D59, 1267-1269. Medline

 

Ricagno S, Jonsson S, Richards N and Lindqvist Y.(2003) Formyl-CoA transferase encloses the CoA binding site at the interface of an interlocked dimer. EMBO J. 22, 3210-3219. Medline


Ricagno S, Jonsson S, Richards N and Lindqvist Y. (2003) Crystallization and preliminary crystallographic analysis of formyl-CoA tranferase from Oxalobacter formigenes. Acta Crystallogr D59,1276-1277. Medline


Moche M, Shanklin J, Ghoshal A, and Lindqvist Y. (2003) Azide and acetate complexes plus two iron-depleted crystal structures of the di-iron enzyme delta9 stearoyl-acyl carrier protein desaturase. Implications for oxygen activation and catalytic intermediates. J Biol Chem. 278, 25072-25080. Medline


Lindqvist Y. (2003) A new kinase fold. Structure. 11, 241-2. Medline


Schutz A, Sandalova T, Ricagno S, Hubner G, Konig S and Schneider G. (2003) Crystal structure of thiamindiphosphate-dependent indolepyruvate decarboxylase from Enterobacter cloacae, an enzyme involved in the biosynthesis of the plant hormone indole-3-acetic acid. Eur J Biochem. 270, 2312-21. Medline

 

2002

 
Schneider G and Sprenger GA (2002) Transaldolase B: Trapping of Schiff base intermediate between dihydroxyacetone and epsilon-amino group of active-site lysine residue by borohydride reduction. Method. Enzymol. 354, 197-201 .


Xu, D., Enroth, C., Lindqvist, Y., Ballou D. P. and  Massey, V. (2002) Studies of the mechanism of phenol hydroxylase: effect of mutation of proline 364 to serine. Biochemistry 41, 13627-36 .  Medline


Achour, A.,  Michaëlsson , J., Harris, R. A., Odeberg, J., Grufman, P.,Sandberg, J. K., Levitsky, V.,  Kärre, K., Sandalova, T. and Schneider, G. (2002) Structural Basis for LCMV Immune Evasion: Subversion of H-2D b and H-2Kb Presentation of gp33 Revealed by Comparative Crystal Structure Analyses. Immunity 17, 757-768. Medline


van Kuilenburg, A. B., Dobritzsch, D., Meinsma, R., Haasjes J., Waterham, H. R., Nowaczyk, M. J., Maropoulos, GD, Hein G., Kalhoff, H., Kirk, J.M., Baaske, H., Aukett, A., Duley, J.A., Ward, K.P., Lindqvist, Y., van Gennip, A.H. (2002) Novel disease-causing mutations in the dihydropyrimidine dehydrogenase gene interpreted by analysis of the three-dimensional protein structure. Biochem. J. 15, 157-63. Medline


Sandmark, J., Mann, S., Marquet, A., and Schneider, G. (2002) Structural basis for the inhibition of the biosynthesis of biotin by the antibiotic amiclenomycin. J. Biol. Chem. 45, 43352-43358.  Medline


Eliot, A.C., Sandmark, J., Schneider,G. and Kirsch, J. F. (2002) The dual-specific active site of 7,8-diaminopelargonic acid synthase and the effect of the R391A mutation. Biochemistry 41, 12582-12589. Medline


Kashuba E, Kashuba V, Sandalova T, Klein G, and Szekely L. (2002).Epstein-Barr virus encoded nuclear protein EBNA-3 binds a novel human uridine kinase/uracil phosphoribosyltransferase. BMC Cell Biol. 3, 23. Medline


Thorell, S., Schürmann, M., Sprenger, G.A. and Schneider, G. (2002) Crystal structure of decameric fructose-6-phosphate aldolase from Escherichia coli reveals inter-subunit helix swapping as the structural basis for assembly differences in the transaldolase family. J. Mol. Biol. 319, 161-171 Medline


Kaija, H., Alatalo, S.L., Halleen, J.M., Lindqvist, Y., Schneider, G., Kalervo Väänänen, H., and Vihko, P. (2002) Phosphatase and oxygen radical generating activities of mammalian purple acid phosphatase are functionally independent. Biochem. Biophys. Res. Commun. 292, 128-132  Medline


Kraft, L., Sprenger, GA., Lindqvist, Y. (2002) Conformational Changes During the Catalytic Cycle of Gluconate Kinase as Revealed by X-ray Crystallography .   J Mol. Biol., 318 , 1057-1069 Medline


Velloso L.M., Svensson K., Schneider G., Pettersson R.F., Lindqvist Y. (2002) Crystal structure of the carbohydrate recognition domain of p58/ERGIC-53, a protein involved in glycoprotein export from the endoplasmic reticulum. J. Biol.Chem. 277,  15979-15984.  Medline


Velloso L.M., Svensson K., Lahtinen U., Schneider G., Pettersson R.F., Lindqvist Y. (2002) Expression, purification, refolding and crystallization of the carbohydrate-recognition domain of p58/ERGIC-53, an animal C-type lectin involved in export of glycoproteins from the endoplasmic reticulum. Acta Crystallogr.  D58 , 536-538.  Medline


Dobritzsch D., Ricagno S., Schneider G., Schnackerz K.D., Lindqvist Y. (2002) Crystal structure of the productive ternary complex of dihydropyrimidine dehydrogenase with NADPH and 5-iodouracil: implications for mechanism of inhibition and electron transfer. J Biol Chem. 277, 13155-13166.  Medline


Fiedler E, Thorell S, Sandalova T, Golbik R, Konig S, Schneider G. (2002) Snapshot of a key intermediate in enzymatic thiamin catalysis: Crystal structure of the alpha -carbanion of (alpha,beta-dihydroxyethyl)-thiamin diphosphate in the active site of transketolase from Saccharomyces cerevisiae. Proc Natl Acad Sci U S A. 99 , 591-595. Medline

 

2001

 

 

Stehr M, Schneider G, Åslund F, Holmgren A, Lindqvist Y (2001) Structural basis for the thioredoxin-like activity profile of the glutaredoxin-like protein NrdH-redoxin from Escherichia coli.    J Biol Chem. 276, 35836-35841 Medline


Sandalova T., Zhong L., Lindqvist Y., Holmgren A., Schneider G. (2001) Three-dimensional structure of a mammalian thioredoxin reductase: Implications for mechanism and evolution of a selenocysteine-dependent enzyme.   Proc Natl Acad Sci U S A . 98, 9533-9538. Medline


Schneider G, Lindqvist Y  (2001) Structural enzymology of biotin biosynthesis. FEBS Lett . 495 , 7-11. Medline


Kraft L, Sprenger GA, and Lindqvist Y (2001) Crystallization and preliminary X-ray crystallographic studies of recombinant thermoresistant gluconate kinase GntK from Escherichia coli. Acta Cryst., D57 , 1159-1161. Medline


Dobritzsch D, Schneider G, Schnackerz KD and Lindqvist Y (2001) Crystal structure of dihydropyrimidine dehydrogenase, a major determinant of the pharmacokinetics of the anti-cancer drug 5-fluorouracil.  EMBO J.  20, 650-660. Medline


Fiedler  E., Golbik  R.,  Schneider  G.,Tittmann  K., Neef  H., König  S. and Hübner  G. (2001) Examination of Donor Substrate Conversion in Yeast Transketolase. J. Biol. Chem. 276, 16051-16058. Medline


Moche M, Dehesh K, Edwards P, Lindqvist Y. (2001) The Crystal Structure of beta-Ketoacyl-Acyl Carrier Protein Synthase II from Synechocystis sp. at 1.54 A Resolution and Its Relationship to Other Condensing Enzymes. J Mol Biol. 305, 491-503. Medline


Dobritzsch D., Persson K., Schneider G. and Lindqvist Y. (2001) Crystallization and preliminary X-ray study of pig liver dihydropyrimidine dehydrogenase. Acta Cryst.  D57 , 153–155 Medline


Schörken  U , Thorell  S, Schürmann  M., Jia  J, Sprenger  GA, and Schneider G. (2001) Identification of catalytically important residues in the active site of Escherichia coli transaldolase. Eur. J. Biochem. 268, 2408-2415. Medline

 

2000

 
Johansson E, Steffens JJ, Lindqvist Y and Schneider G. (2000) Crystal Structure of Saccharopine Reductase from Magnaporthe grisea, an Enzyme of the alpha-Aminoadipate Pathway of Lysine Biosynthesis. Structure, 8 , 1037-1047. Medline


Kärre  K  and Schneider  G  (2000) The footprint of a killer. Nature, 405, 527-528 Medline


Persson  K. and Schneider  G. (2000) Three-dimensional structures of MHC class I – peptide complexes: implications for peptide recognition. Archivum Immunologiae & Therapiae experimentalis. 48 , 135-142 Medline

 

Schneider G, Käck H and LindqvistY. (2000) The manifold of vitamin B6 dependent enzymes. Structure, 8 , R1-R6 Medline


Val D, Banu G, Seshadri K, Lindqvist Y  and Dehesh K. (2000) Re-engineering ketoacyl synthase specificity. Structure, 8, 565-56 Medline


Johansson E, Steffens JJ, Emptage M, LindqvistY and Schneider G. (2000) Cloning, expression, purification and crystallization of saccharopine reductase from Magnaporthe grisea. Acta Cryst. D56 , 662–664
Medline


Zhong L, Persson K, Sandalova T, Schneider G and Holmgren A. (2000) Purification, crystallisation and preliminary crystallographic data for rat cytosolic selenocysteine-498 to cysteine mutant thioredoxin reductase. Acta Crystallogr. D56 , 1191-1193 Medline


Svensson S, Höög J.-O, Schneider G and Sandalova T. (2000) Crystal structures of mouse class II alcohol dehydrogenase reveal determinants of substrate specificity and catalytic efficiency. J. Mol. Biol. 302 , 441-453 Medline


Thorell S, Gergely P, Banki K, Perl A and Schneider G. (2000) The three-dimensional structure of human transaldolase. FEBS Lett. 475, 205-208 Medline


Hecquet L, Demuynck C, Schneider G and Bolte J. (2000) Enzymatic synthesis of ketoses: study and modification of  the subtstrate specificity of transketolase from Saccharomyces cerevisiae. Proceedings of Biotrans ’99 .
Medline

 
Lu G, Dobritzsch D, Baumann S, Schneider G and König S. (2000) The structural basis of substrate activation in yeast pyruvate decarboxylase. Eur. J. Biochem. 267 , 861-868 Medline

 

1999

 

 Persson K, Schneider G, Jordan DB, Viitanen PV, and  Sandalova T. (1999) Crystal structure analysis of a pentameric fungal and an icosahedral plant lumazine synthase reveals the structural basis for differences in assembly. Protein Sci. 8 , 2355-2365 Medline


Gotthardt Olsen J, Kadziola A, von Wettstein-Knowles  P, Siggaard-Andersen M, Lindqvist Y, & Larsen S  (1999) The X-ray crystal structure of beta-ketoacyl [acyl carrier protein] synthase I FEBS Letters , 460 , 46-52 Medline


Käck H, Sandmark J, Gibson K, Schneider G, & Lindqvist Y. (1999) Crystal Structure of Diaminopelargonic Acid Synthase: Evolutionary Relationships between Pyridoxal-5’-phosphate-dependent Enzymes. J. Mol. Biol. 291 , 857-876 Medline


Lindqvist Y, Johansson E, Kaija H, Vihko P & Schneider G. (1999) Three-dimensional Structure of a Mammalian Purple Acid Phosphatase at 2.2Å Resolution with a mu-(Hydr)oxo Bridged Di-iron Center. J. Mol. Biol. 291, 135-147 Medline


Witkowski A, Joshi AK, Lindqvist Y. & Smith S. (1999) Conversion of beta-ketoacyl synthase to a malonyl decarboxylase by replacement of the active site cysteine with glutamine. Biochemistry, 38, 11643-11650 Medline


Morgunova E, Tuuttila A, Bergmann U, Isupov M, Lindqvist Y, Schneider G, & Tryggvason K. (1999) Structure of Human Pro-Matrix Metalloproteinases-2: Activation Mechanism Revealed. Science, 284, 1667-1670 Medline


Wawrzak Z, Sandalova T, Steffens JJ, Basarab GS, Lundqvist T, Lindqvist Y, & Jordan  DB. (1999) High-resolution structures of scytalone dehydratase-inhibitor complexes crystallized at physiological pH.  Proteins, 35, 425-439 Medline


Rendina  AR, Taylor WS, Gibson K, Lorimer G, Rayner D, Locket B, Kranis K, Wexler B, Hongji C, Wawrzak Z, Calabrese J, Huang W, Jia J, Schneider G, Lindqvist Y & Yang G. (1999) The design and synthesis of inhibitors of dethiobiotin synthetase as potential herbicides. Pestic. Sci. 55, 236-247 Medline

 

Kaija,H., Jia,J., Lindqvist,Y., Andersson,G. & Vihko,P. (1999) Tartrate-resistant bone acid phosphatase: large-scale production and purification of the recombinant enzyme, characterization, and crystallization. J. Bone Min. Res. 14, 424-429 Medline


Moche, M., Schneider,G., Edwards,P., Dehesh,K. & Lindqvist Y. (1999) Structure of the complex between the antibiotic cerulenin and its target, beta-Ketoacyl-ACP synthase. J. Biol. Chem. 274 , 6031-6034 Medline


Hübner, G., Tittmann, K., Killenberg-Jabs, M., Schäffner, J., Spinka, M., Neef, H., Kern, D., Kern, G., Schneider, G., Wikner, C. and Ghisla, S. (1999) Activation of thiamin diphosphate in enzymes. Biochem. Biophys. Acta 1385 , 221-228 Medline


Sandalova, T., Schneider,G., Käck, H., & Lindqvist,Y. (1999) Crystal structure of dethiobiotin synthetase at 0.97Å resolution. Acta Cryst Sect. D55, 610-624 Medline

 

1998

 

Schneider,G and Lindqvist,Y. (1998) Crystallography and mutagenesis of transketolase: implications for enzymatic thiamin catalysis. Biochem. Biophys. Acta. 1385 , 387-398 Medline


Dobritzsch, D., König, S., Schneider, G. and Lu, G. (1998) High resolution structure of pyruvate decarboxylase from Zymomonas mobilis: implications for substrate activation in pyruvate decarboxylases.
J. Biol. Chem. 273 , 20196-20204 Medline


Schörken, U., Jia, J., Sahm, H., Sprenger, G.A. and Schneider, G. (1998) Disruption of Escherichia coli transaldolase into catalytically active monomers: evidence against half-of-the-sites mechanism. FEBS Lett 441, 247-250
Medline


Mkrtchian, S., Baryshev, M., Matvijenko, O., Sharipo, A., Sandalova, T., Schneider, G., Ingelman-Sundberg, M. (1998) Oligomerization properies of ERp29, an endoplasmatic reticulum stress protein. FEBS Lett.431, 322-326
Medline


Nilsson, U., Hecquet, L., Gefflaut, T., Guerard, C. and Schneider, G. (1998) Asp477 is a determinant of the enantioselectivity in yeast transketolase. FEBS Lett.424 , 49-52
Medline


Tuuttila,A., Morgunova,E., Bergmann,U., Lindqvist,Y., Maskos,K., Fernandez-Catalan,C., Bode,W., Tryggvason,K. & Schneider,G. (1998) Three-dimensional structure of human tissue inhibitor of metalloproteinases-2 at 2.1Å resolution. J. Mol. Biol. 284 , 1133-1140
Medline


Käck,H., Sandmark,J., Gibson,K.J., Schneider, G., & Lindqvist, Y. (1998) Crystal structure of two quaternary complexes of dethiobiotin synthetase, enzyme MgADP-AlF3-diaminopelargonic acid and enzyme-MgADP-dethiobiotin-phosphate; implications for catalysis. Protein Science 7 , 2560-2566
Medline


Achour,A., Persson,K., Harris,R.A., Sundbäck,J., Sentman,C.L., Lindqvist,Y., Schneider,G. & Kärre, K. (1998) The crystal structure of H-2Dd MHC class I complexed with the HIV derived peptide P18-I10 at 2.4Å resolution: implications for T-cell and Natural Killer cell recognition. Immunity , 9 , 199-208
Medline


Achour,A., Harris,R.A., Persson,K., Sundbäck,J., Sentman,C.L., Schneider,G., Lindqvist,Y. & Kärre, K. (1999) Murine MHC class I H-2Dd complex: expression, refolding, and crystallization. Acta Crystallogr . D55 , 260
Medline


Käck,H., Gibson,K.J., Gatenby A.A., Schneider,G., & Lindqvist,Y. (1998) Purification and preliminary X-ray crystallographic studies of recombinant 7,8-diaminopelargonic acid synthase from Escherichia coli. Acta Crystallogr . D54 , 1397-1398
Medline
 

Enroth C., Neujahr H., Schneider G., Lindqvist Y. (1998) The crystal structure of phenol hydroxylase in complex with FAD and phenol provides evidence for a concerted conformational change in the enzyme and its cofactor during catalysis. Structure 6 , 605-617. Medline


Käck,H., Gibson,K.J., Lindqvist,Y.and Schneider,G. (1998) Snapshot of a phosphorylated substrate intermediate by kinetic crystallography Proc. Natl. Acad. Sci. USA, 95, 5495-5500
Medline


Huang,W., Jia,J., Edwards,P., Dehesh,K., Schneider,G. and Lindqvist,Y. (1998) Crystal structure of beta-keto-acyl carier protein synthase II from  E. coli reveals the molecular architecture of condensing enzymes. EMBO J. , 17 , 1183-1191
Medline

 

1997

 

Wikner,C., Nilsson,U., Meshalkina,L., Udekwu,C., Lindqvist,Y. and Schneider,G. (1997) Identification of Catalytically Important Residues in Yeast Transketolase. Biochemistry, 36 , 15643-15649 Medline


Schneider,G and Lindqvist,Y. (1998) Crystallography and mutagenesis of transketolase: implications for enzymatic thiamin catalysis. Biochem. Biophys. Acta. 1385, 387-398 Medline


Schneider,G. and Lindqvist,Y. (1997) Structure of ATP-Dependent Carboxylase, Dethiobiotin Synthase Methods in Enzymology , 279, 376-385 Medline


Lindqvist,Y and Schneider,G (1997) Circular permutations of natural protein sequences: structural evidence Curr. Opinion in Struct. Biol. 7, 422-427 Medline


Cahoon,E.B., Lindqvist,Y., Schneider,G. and Shanklin,J.(1997)  Redesign of soluble fatty acid desaturases from plants for altered substrate specificity and double bond position. Proc. Natl. Acad. Sci. USA, 94, 4872-4877 Medline


Stenberg,K. and Lindqvist,Y. (1997) Three-dimensional structures of glycolate oxidase with bound active-site inhibitors. Protein Science 6 , 1009-1015 Medline


Huang,W., Jia,J., Cummings,J., Nelson,M., Schneider,G. and Lindqvist,Y. (1997) Crystal structure of nitrile hydratase reveals a novel iron centre in a novel fold. Structure 5 , 691-699 Medline


Yang,G., Sandalova,T., Lohman,K., Lindqvist,Y. and Rendina A.R. (1997) Active Site Mutants of Escherichia coli Dethiobiotin Synthetase: Effects of Mutations on Enzyme Catalytic and Structural Properties. Biochemistry 36 , 4751-4760 Medline


Thompson,J.E., Basarab,G.S., Andersson,A., Lindqvist,Y. and Jordan,D.B. (1997) Trihydroxynaphtalene reductase from Magnaporthe grisea: Realization of an active center inhibitor and elucidation of the kinetic mechanism. Biochemistry 36 , 1852-1860 Medline


Kern, D., Kern, G., Neef, H., Tittmann, K., Killenberg-Jabs, M., Wikner, C., Schneider, G. and Hübner, G. (1997) How thiamin diphosphate is activated in enzymes. Science 275 , 67-70 Medline


Meshalkina, L., Nilsson, L., Wikner, C., Kostikowa, T. and Schneider, G. (1997) Examination of the thiamin diphosphate binding site in yeast transketolase by site-directed mutagenesis. Eur. J. Biochem. 244, 646-652 Medline


Lu, G., Dobritzsch, D., König, S. and Schneider, G. (1997) Novel tetramer assembly of pyruvate decarboxylase from brewer’s yeast observed in a new crystal form. FEBS Lett. 403 , 249-253 Medline


Jia,J., Schörken,U., Lindqvist, Y., Sprenger G.A. and Schneider,G. (1997) Crystal structure of the reduced Schiff-base intermediate complex of transaldolase B from Escherichia coli: Mechanistic implications for class I aldolases. Protein Science 6, 119-124. Medline


Nilsson,U., Meshalkina,L., Lindqvist,Y. and Schneider,G. (1997) Examination of substrate binding in thiamin diphosphate-dependent transketolase by protein crystallography and site-directed mutagenesis. J. Biol. Chem. 272 , 1864-1869
Medline


Andersson,A., Jordan,D., Schneider,G. and Lindqvist, Y. (1997) A flexible lid controls access to the active site in 1,3,8-trihydroxynaphtalene reductase. FEBS Letters  400 , 173-176 Medline

 

1996

 

Lindqvist,Y and Schneider,G (1996) Protein-biotin interactions. Curr. Opinion in Struct. Biol. 6 , 798-803 Medline


Andersson,A., Jordan,D., Schneider,G. and Lindqvist, Y. (1996) Crystal structure of the ternary complex of 1,3,8-trihydroxynaphtalene reductase from Magnaporthe grisea  with NADPH and an active site inhibitor. Structure  4, 1161-1170
Medline


Stenberg,K. and Lindqvist,Y. (1996) High level expression, purification and crystallization of recombinant spinach glycolate oxidase in Escherichia coli. Protein Expr and Purif. 8 ,  295-298
Medline


Lindqvist,Y., Huang,W., Schneider,G. and Shanklin,J. (1996) Crystal structure of delta9 stearoyl-acyl carrier protein desaturase from Castor seed and its relationship to other diiron proteins. EMBO J . 15, 4081-4092 Medline


Jia,J., Huang,W., Schörken,U., Sahm,H., Sprenger,G. A., Lindqvist,Y. and Schneider,G. (1996) Crystal structure of transaldolase B from Escherichia coli  suggests a circular permutation of the alpha/beta barrel within the class I aldolase family. Structure 4, 715-724 Medline

 

Zhang,Q-J., Lindqvist,Y., Levitsky,V. and Masucci, M. (1996) Solvent exposed side chains of peptides bound to HLA A11 have similar effects on the reactivity of alloantibodies and specific T cell receptors. Int. Immunol. 8 , 927-938 Medline

 

Andersson,A., Jordan,D., Schneider,G., Valent,B., and Lindqvist,Y. (1996) Crystallization and preliminary X-ray diffraction study of 1,3,8-trihydoxynaphtalene reductase from Magnaporthe grisea. PROTEINS. 24 , 525-527 Medline


Jia,J., Lindqvist,Y., Schneider,G., Schörken,U., Sahm,H. and Sprenger,G.A. (1996) Crystallization and preliminary X-ray crystallographic analysis of recombinant transaldolase B from Escherichia coli. Acta Cryst.D52, 192-193 Medline

 

1995

 

Sandalova,T. and Lindqvist,Y. (1995) Three-Dimensional Model of the alpha-Subunit of Bacterial Luciferase PROTEINS 23 , 241-255 Medline

 
Wikner,C., Meshalkina,L., Nilsson,U., Bäckström,S., Lindqvist,Y. and Schneider,G. (1995) His103 in yeast transketolase is required for substrate recognition and catalysis. Eur. J. Biochem . 233 , 750-755 Medline


Andersson,A., Schneider,G. and Lindqvist,Y. (1995) Purification and preliminary X-ray crystallographic studies of recombinant L-ribulose-5-phosphate 4-epimerase from Escherichia coli. Protein Science 4, 1648-1650 Medline


Huang,W., Jia,J., Gibson,K.J., Taylor,W.S., Rendina,A.R., Schneider,G., Lindqvist,Y. (1995) Mechanism of an ATP-Dependent Carboxylase, Dethiobiotin Synthetase, Based on Crystallographic Studies of Complexes with Substrates and a Reaction Intermediate. Biochemistry 34 , 10985-10995 Medline


Lu,G., Lindqvist,Y., Schneider,G., Dwivedi,U., Campbell,W. (1995) Structural Studies on Corn Nitrate Reductase: Refined Structure at 2.5Å , its ADP Complex And an Active-site Mutant and Modeling of the Cytochrome b Domain. J.Mol.Biol. 248 , 931-948 Medline


Stenberg,K., Clausen,T., Lindqvist,Y., Macheroux, P.(1995) Involvement of Tyr24 and Trp108 in substrate binding and substrate specificity of glycolate oxidase. Eur. J. Biochem. 228 , 408-416 Medline


Lu,G.G., Lindqvist,Y., Schneider,G. (1995) A Method for Processing Diffraction Data from Twinned Protein Crystals and its Application in the Structure Determination of an FAD/NADH-Binding Fragment of Nitrate Reductase Acta Cryst. D51 , 13-20 Medline

 

1994

 

Wikner,C., Meshalkina,L., Nilsson,U., Nikkola,M., Lindqvist,Y., Sundström,M., and Schneider,G. (1994) Analysis of an invariant cofactor-protein interaction in thiamin diphosphate-dependent enzymes by site-directed mutagenesis. J. Biol. Chem. 269 , 32144-32150 Medline


Lundqvist,T., Rice,J., Pierce,J. and Lindqvist Y. (1994) Crystal structure of scytalone dehydratase -a disease determinant of the rice pathogen, Magnaporthe grisea. Structure , 2 , 937-944 Medline


Porvari,K.S., Herrala,A.M., Kurkela,R.M., Taavitsainen,P.A., Lindqvist,Y., Schneider,G. & Vihko,P.T. (1994) Site-directed mutagenesis of prostatic acid phosphatase J. Biol. Chem. 269 , 22642-22646 Medline


Lu, G.G., Campbell,W.H., Schneider,G. & Lindqvist,Y. (1994) Crystal structure of the FAD-containing fragment of corn nitrate reductase at 2.5 Å  resolution: relationship to other flavoprotein reductases. Structure 2 , 809-821 Medline


Huang,W.,. Lindqvist Y., Schneider, G., Gibson, K., Flint,D. & Lorimer,G. (1994) Crystal Structure of an ATP-dependent carboxylase, dethiobiotin synthetase, at 1.65 Å  resolution. Structure 2 , 407-414 Medline


Lindqvist,Y., Schneider,G. & Vihko,P. (1994) Crystal Structure of Rat Acid Phosphatase Complexed with the Transition State Analogs Vanadate and Molybdate: Implications for the Reaction Mechanism Eur. J. Biochem. 221 , 19-142 Medline


Schneider, G. (1994) Carbon dioxide fixation in biology: structure and function of ribulose bisphosphate carboxylase/oxygenase in CO2 chemistry: environmental issues (J. Paul and C.M. Pradier, eds), pp. 150-159 ,  Royal Society of Chemistry, Cambridge, UK Medline

 

Schneider, G. and Lindqvist Y. (1994) Ta6Br14 is a useful cluster compound for isomorphous replacement in protein crystallography. Acta Cryst. D50 , 186-191 Medline

 

Enroth,C., Huang,W., Waters,S., Neujahr,H., Lindqvist,Y., Schneider,G. (1994) Crystallization and Preliminary X-ray Analysis of Phenol Hydroxylase from Trichosporon cutaneum J. Mol. Biol . 238 , 128-130 Medline


Nikkola,M., Lindqvist,Y. and Schneider,G. (1994) Refined Structure of Transketolase from Saccharomyces cerevisae at 2.0 Å  resolution J. Mol. Biol . 238 , 387-404 Medline


König, S., Schellenberger, A., Neef, H. and Schneider, G. (1994) Specificity of coenzyme binding in thiamin diphosphate enzymes: crystal structures of yeast transketolase in complex with analogs of thiamin diphosphate. J. Biol. Chem 269 , 10879-10882 Medline

 

1993

 

Lindqvist, Y., Schneider, G.  and Vihko, P. (1993) Three-Dimensional Structure of Rat Acid Phosphatase in Complex with L(+) Tartrate J. Biol Chem. 268, 20744-20746 Medline


Lindqvist,Y and Schneider,G (1993) Thiamindiphosphate dependent enzymes: transketolase, pyruvate oxidase and pyruvate decarboxylase. Curr. Opinion in Struct. Biol. 3 , 896-901 Medline

 

Muller,Y.A., Lindqvist,Y., Furey,W., Schulz,G.E., Jordan,F. and Schneider,G. (1993) A Thiamine Diphosphate Binding Fold Revealed by Comparison of the Crystal Structures of Transketolase, Pyruvate Oxidase and Pyruvate Decarboxylase Structure , 1 , 95-103 Medline


Sundström, M, Lindqvist,Y., Schneider,G., Hellman,U. and Ronne,H. (1993) Yeast TKL1 gene encodes a transketolase that is required for efficient glycolysis and biosynthesis of aromatic amino acids. J.Biol.Chem. 268 , 24346-24352 Medline


Schneider,G., Lindqvist,Y. and Vihko,P. (1993) Three-Dimensional Structure of Rat Acid Phosphatase EMBO J.  12, 2609-2615 Medline


Nilsson,U., Lindqvist,Y., Kluger,R. and Schneider,G. (1993) Crystal Structure of Transketolase in Complex with Thiamin Thiazolone DiPhosphate, an Analogue of the Reaction Intermediate, at 2.3Å  Resolution. FEBS Letters 326, 145-148 Medline


Sandalova,T. and Lindqvist,Y. (1993) Crystal Structure of Apo-Glycolate Oxidase FEBS Letters, 327 , 361-365 Medline


Vihko, P., Kurkela,R., Porvari,K. Herrala,A., Lindfors,A. Lindqvist,Y. and Schneider,G. (1993) Rat acid phosphatase: Overexpression of active, secreted enzyme by recombinant baculovirus-infected insect cells, molecular properties and crystallization. Proc. Natl. Acad. Sci. U.S.A. 90 , 799-803 Medline


Schneider,G. and Lindqvist,Y. (1993) Enzymatic thiamine catalysis: mechanistic implications from the three-dimensional structure of transketolase. Bioorg. Chem. 21 , 109-117 Medline

 

Macheroux,P., Kieweg,V., Massey,V., Söderlind.E., Stenberg,K. and Lindqvist,Y. (1993) Role of tyrosine 129 in the active site of spinach glycolate oxidase. Eur.J.Biochem. , 1047-1054 Medline


Ekström,T.J., Bäcklin,B.M., Lindqvist,Y. and Engström,W. (1993) Insulin-Like Growth Factor II in the Mink (Mustela vison): Determination of a cDNA Nucleotide Sequence and Developmental Regulation of Its Expression. Gen. Comp. Endocrin. 90 , 243-250 Medline


Schneider, G. (1993) Photosynthetic carbon dioxide fixation: Structural and functional aspects of ribulose bisphosphate carboxylase/oxygenase in Proceedings of the Royal Academy of Sciences Nobel Symposia: Carbon dioxide fixation and reduction in biological and model systems (Brändén, C.-I. and Schneider, G., eds.), Oxford University Press, pp.1-17 Medline

 

1992

 

Schneider,G., Lindqvist,Y., Shanklin,J. and Somerville,C. (1992) Preliminary Crystallographic Data for Stearoyl-Acyl Carrier Protein Desaturase from Castor Seed. J. Mol. Biol. 225 , 561-564 Medline

Lindqvist,Y. (1992) Structure and mechanism of glycolate oxidase in Chemistry and Biochemistry of Flavoenzymes, Vol III , F. Müller, ed., CRC Press, pp.367-387 Medline

Schneider,G. and Lindqvist,Y. (1992) Structural constraints on protein engineering in Plant Protein Engineering (P. Shewry and S. Gutteridge, eds.), Cambridge Univ. Press, pp.42-58 Medline


Schneider,G., Lindqvist,Y. and Brändén,C.-I. (1992) Rubisco: Structure and Mechanism  Ann. Rev. of Biophys. 21 , 119-143
Medline

Sundström, M., Lindqvist,Y. and Schneider,G. (1992) Three-dimensional structure of apotransketolase. Flexible loops at the active site enable cofactor binding . FEBS Letters 313 , 229-231 Medline


Lu,G.G., Lindqvist,Y. and Schneider,G. (1992) Electrostatic Fields at the Active Site of Ribulose-1,5-bisphosphate Carboxylase PROTEINS , 12, 117-127
Medline


Lu,G.G., Campbell,W., Lindqvist,Y. and Schneider,G. (1992) Crystallization and Preliminary Crystallographic Studies of the FAD Domain of Corn NADH:Nitrate Reductase J. Mol. Biol., 224 , 277-279
Medline


Lindqvist,Y., Schneider,G., Ermler,U. & Sundström,M. (1992) Three-dimensional Structure of Transketolase from baker´s yeast, a Thiamine Diphosphate dependent enzyme. EMBO J. 11 , 2373-2379
Medline


Söderlind,E., Schneider,G. and Gutteridge,S. (1992) Substitution of Asp193 by Asn at the active site of ribulose-1,5-bisphosphate carboxylase results in conformational changes Eur. J. Biochem. 206 , 729-735
Medline

 

1991

 

Lindqvist,Y., Brändén,C.-I., Mathews,S. and Lederer,F. (1991) Spinach Glycolate Oxidase and Yeast Flavocytochrome b2 are Structurally Homologous and Evolutionary Related Enzymes with Distinctly Different Function and FMN-binding. J. Biol. Chem.  266 , 3198-3207 Medline


Brändén,C.-I., Lindqvist,Y. and Schneider,G. (1991) Protein Engineering of Rubisco Acta Cryst.  B47, 824-835 Medline


Lundqvist,T. and Schneider,G. (1991) Crystal structure of ribulose-1,5-bisphosphate carboxylase, Mg(II) and activator CO2   Biochemistry 30 , 904-908 Medline


Lundqvist,T. and Schneider,G. (1991) Crystal structure of activated ribulose-1,5-bisphosphate carboxylase, complexed with its substrate, ribulosebisphosphate.  J. Biol. Chem. 266 , 12604-12611 Medline

 

1990

 

Ranty, B., Lundqvist, T., Schneider, G., Madden, M., Howard, R. and Lorimer, G.  (1990) Truncation of ribulose -1,5- bisphosphate carboxylase from Rhodospirillum rubrum affects the assembly and activity of the protein  EMBO J. 9,  1365-1373 Medline


Schneider,G., Lindqvist,Y. and Lundqvist,T. (1990) Crystallographic refinement and structure of Ribulose-1,5-bisphosphate Carboxylase from Rhodospirillum rubrum at 1.7Å  resolution J. Mol. Biol., 211, 989-1008 Medline


Schneider,G. Andersson,I. Brändén,C.-I. Knight,S., Lindqvist,Y. and Lundqvist,T. (1990) Comparison of the crystal structures of L2 and L8S8 Rubisco suggests a functional role for the small subunit . EMBO J. 9 , 2045-2050 Medline

 

1989

 

Andersson ,I., Knight,S., Schneider,G., Lindqvist,Y., Lundqvist,T., Brändén,C.-I. and Lorimer,G.H. (1989) Crystal Structure of the Active Site of Ribulose-bisphosphate Carboxylase . Nature , 337, 229-234 Medline

 

Lindqvist,Y. and Brändén,C.-I. (1989) The active site of spinach glycolate oxidase J. Biol. Chem. 264, 3624-3628 Medline


Lindqvist,Y. (1989) Refined structure of spinach glycolate oxidase at 2Å  resolution J. Mol. Biol. 209, 151-161 Medline


Schneider,G., Sundström,M. and Lindqvist,Y. (1989) Preliminary crystallographic data for transketolase from yeast . J. Biol. Chem. 264 , 21619-21620 Medline


Lundqvist,T. and Schneider,G. (1989) Crystal structure of the binary complex of ribulose 1,5 bisphosphate carboxylase and its product, 3- phospho-glycerate J. Biol. Chem. 264 , 3643 - 3646 Medline


Lundqvist,T. and Schneider,G. (1989) Crystal structure of the complex of ribulose-1,5- bisphosphate carboxylase and a transition state analogue, 2-carboxy-D-arabinitol 1,5 bisphosphate J.Biol. Chem.  264, 7078 - 7083 Medline

 

1988

 

Cederlund,E., Lindqvist,Y., Söderlund,G., Brändén,C.-I. and Jörnvall, H. (1988) Primary Structure of Glycolate Oxidase from Spinach. Eur. J. Biochem. 173 , 523-530 Medline

 

1986

 

Schneider,G., Lindqvist,Y., Brändén,C.-I. and Lorimer,G. (1986) Three-dimensional Structure of Ribulose-1,5-bisphosphate Carboxylase/Oxygenase from Rhodospirillum rubrum  at 2.9Å  resolution. EMBO J. 5, 3409-3415 Medline

 

Eklund, H., Jones, T.A. and Schneider,G. (1986) Active site in Alcohol dehydogenase in Zinc enzymes (Bertini,I., Luchinat,-C., Maret,W. and  Zeppezauer,M.,ed.) pp 377 - 392, Birkhauser Boston,Inc. Medline

 

Schneider,G., Brändén, C.-I. and Lorimer,G. (1986) New crystal forms of ribulose-1,5-phosphate carboxylase/ oxygenase from Rhodospirillum rubrum J. Mol. Biol. 187 , 141 - 143 Medline

 

1985

 

Lindqvist,Y. and Brändén,C.-I. (1985) Structure of Glycolate Oxidase from Spinach Proc. Natl. Acad. Sci. U.S.A. 82, 6855-6859 Medline

 

Schneider,  G.,  Cedergren-Zeppezauer, E., Knight, S., Eklund, H., and  Zeppezauer, M. (1985) Acitve site specific Cadmium(II)-substituted Horse liver alcohol dehydrogenase: Crystal structures of the free enzyme, its binary complex with NADH and the ternary complex with NADH and bound p- bromobenzyl alcohol   Biochemistry , 24 , 7503 - 7510 Medline

 

1984

 

Zeppezauer, M., Andersson, I., Dietrich, H., Gerber, M., Maret, W., Schneider, G. and Schneider-Bernlohr,H. (1984) Coordination chemistry and function of the  catalytic metal ion in liver alcohol dehydrogenase . J. Mol. Cat. 23, 377 - 387 Medline


Schneider,G., Brändén, C.-I. and Lorimer,G. (1984) Preliminary X-ray  diffraction study of ribulose-1,5-phosphate carboxylase from Rhodospirillum rubrum  J. Mol. Biol. 175 , 99-102
Medline

1983

 

Schneider, G., Eklund,H., Cedergren-Zeppezauer,E. and Zeppezauer,M. (1983)  Structure of the complex of active site metal-depleted Horse Liver Alcohol  Dehydrogenase and NADH  EMBO J.  2 , 685 - 689 Medline


Schneider, G., Eklund,H., Cedergren-Zeppezauer,E. and Zeppezauer,M. (1983) Crystal structures of the active site in specifically metal-depleted and cobalt substituted horse liver alcohol dehydrogenase Proc. Natl. Acad. Sci. USA 80 , 5289 - 5293 Medline


Schneider,G. and Zeppezauer,M. (1983) Kinetics and Mechanisms of the  Recombination of Zn(II), Co(II) and Ni(II) with the Metal-Depleted Catalytic Site of Horse Liver Alcohol Dehydrogenase J. Inorg. Biochem. 18, 59 - 69 Medline

 

1980

 

Lindqvist,Y. and Brändén,C.-I. (1980) Structure of Glycolate Oxidase from Spinach at a Resolution of 5.5Å J. Mol. Biol.143, 201-211 Medline

1979

Lindqvist,Y. and Brändén,C.-I. (1979) Preliminary Crystallographic Data  for Glycolate Oxidase from Spinach J. Biol. Chem. 254, 7403-7404 Medline